Radioiodine protection from tincture of iodine
Effectiveness of Skin Absorption of Tincture of I in Blocking Radioiodine from the Human Thyroid Gland
- Miller KL
- Coen PE
- White WJ
- Hurst WJ
- Achey BE
- Lang CM
Health Physics, Vol. 56, No. 6, pages 911-914, 13 references, 1989
Using 24 healthy adult male subjects, a study was carried out to determine the effectiveness of the topical application of tincture of iodine (7553562) (I) in blocking the thyroid uptake of orally administered iodine-131 (I131) in humans.
Each of the 24 subjects was administered I131 labeled sodium-iodide in orange juice. Of the 24, six subjects formed the comparison group and received no stable-I; six subjects received 4 milliliters (ml) of 2 percent tincture of-I on a single forearm over an area of approximately 200 by 50 millimeters (mm) 2 hours prior to I131 administration; six subjects received 8ml of 2 percent tincture of-I on the abdomen over an area of approximately 200 by 100mm 2 hours prior to I131 administration; and six subjects received an oral dose of 130 milligrams of potassium-iodide (7681110) (KI) 2 hours prior to I131 administration.
Serum-I concentrations peaked at approximately 2 hours after topical application of tincture of-I.
- Subjects receiving 8ml of tincture of-I on the abdomen had 26 hour post application (PA) serum-I levels ranging from 109 to 563 picograms per cubic milliliter (pg/mm3) and thyroid uptakes ranging from 0.20 to 6.7 percent.
- Subjects receiving 4ml of tincture of-I on the forearm had 26 hour PA serum-I levels ranging from 30.1 to 70.6pg/mm3 and thyroid uptakes ranging from 0.9 to 15.3 percent.
- Subjects receiving oral KI had 26 hour PA serum-I levels ranging from 215 to 1010pg/mm3 and thyroid uptakes ranging from 0 to 0.61 percent.
- Comparison subjects had 26 hour PA serum-I levels ranging from 7.24 to 16.5pg/mm3 and thyroid uptakes ranging from 6.5 to 14.8 percent.
Although there were large variations within each subject group in regard to serum-I levels and thyroid uptakes, the increase in serum-I concentration after topical-I application was effective in reducing the thyroid uptake of I131.
The authors conclude that in the absence of KI, most humans would benefit from topical application of tincture of-I, and that in some the effectiveness would equal that of oral KI.
The following table is not part of this paper's abstract.
|Form||Dose||Serum-I lo||Serum-I hi||Uptake lo||Uptake hi|
| portion of|
| portion of|
- Thyroid gland
- Potassium compounds
- Halogen compounds
- Skin absorption
- Radioactive isotopes
CAS REGISTRY NUMBERS
YEAR OF PUBLICATION
SECONDARY SOURCE ID
- Radiation log of ionizing events recorded in the Fulford Valley of Salt Spring Island, British Columbia, Canada.
- Radiation fallout plan for minimizing the impact of radioactive fallout at EcoReality Co-op.
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